The NHS Blood and Transplant (NHSBT) Cellular and Molecular Therapies (CMT) Facility in Barnsley required a high-performance GMP Grade B cleanroom environment to support advanced cell therapy. The project was designed and implemented to ensure compliance with stringent regulatory requirements and operational efficiency.
The cleanroom was developed to meet GMP standards, providing a controlled environment for cell therapy processes while maintaining flexibility and containment.
Key features included:
- Custom Fabric & HVAC System: Designed to maintain ISO-classified environments with precise airflow and pressure regulation
- Optimised Room Pressurisation & Classification: Ensuring seamless material, personnel, and waste flow in compliance with regulatory requirements
- Strategic Cleanroom Support Office Integration – Adjacent unclassified spaces were positioned for efficient workflow processing, enhancing real-time monitoring and compliance.
The HVAC system was engineered for contamination control and energy efficiency, with full GMP validation ensuring regulatory compliance. The NHSBT CMT Facility exemplifies a structured and compliant approach to cleanroom development, balancing regulatory requirements with operational efficiency. This project serves as a reference for future cleanroom initiatives requiring high standards of performance and compliance.
